Role of 5-hydroxytryptamine in Moringa oleifera induced potentiation of pentobarbitone hypnosis in albino rats.
نویسندگان
چکیده
The role of 5-hydroxytryptamine (5-HT) in pentobarbitone (PB) sleeping time, gross behaviour, electrical activity of the brain and serum 5-HT level was studied in Holtzman strain adult albino rats following treatment with M. oleifera (MO). MO (350mg/kg) caused inhibition of awareness, touch response, motor activity, righting reflex, and grip strength. It significantly increased the PB sleeping time, serum 5-HT level (P<0.001) and alpha-wave activity. These observations indicate that the aqueous extract of MO potentiated PB induced sleeping time and increased the alpha-wave activity through 5-HT.
منابع مشابه
Comparative Study of the Hepatoprotective Activities of Vitex Negundo Linn. and Moringa Oleifera Lam. in Paracetamol Induced Hepatotoxicity in Experimental Animals
Aims: To evaluate the hepatoprotective activity of Vitex negundo Linn. and Moringa oleifera Lam. In paracetamol induced hepatotoxicity in rats. Materials and Methods: Liver damage was induced in 42 albino rats by paracetamol (1 g/kg P.O.) once daily for a period of 7 days. Silymarin was taken as the standard drug in a dose of 25 mg/kg P.O. Albino Wistar rats (150-200 g) were divided into groups...
متن کاملAnti-inflammatory effect of Moringa oleifera Lam. seeds on acetic acid-induced acute colitis in rats
Objective: Anti-inflammatory, immuno-modulatory, and antioxidant properties of Moringa oleifera Lam. suggest that it might have beneficial effects on colitis. The present study was performed to investigate the anticolitis effect of Moringa oleifera seeds hydro-alcoholic extract (MSHE) and its chloroform fraction (MCF) on acetic acid-induced colitis in rats. Materials and Methods: Both MSHE and ...
متن کاملAbortifacient Activity of a Medicinal Plant “moringa Oleifera” in Rats
Dried powder of leaf extract of common Indian plant Moringa Oleifera of Moringaceae family was tested experimentally in albino rats in our laboratory for its antifertility activity. Cant per cent abortifacient activity was found when administered orally in aqueous solution at dose of 175 mg/kg body weight daily to Charles foster strain albino rats from days 5-10 post mated.
متن کاملProtective Activity of Moringa Oleifera Leaf Extract on Lindane Induced Testicular Damage in Rats
Exposure of the body organs and systems to pesticides including lindane has found been to cause adverse effects, which affect functionality. Hence, this study was aimed at determining the ability, potency and nature of Moringa oleifera leaf in the protecting testis against lindane induced testicular damage based on some biochemical and histopathological parameters. Adult male rats were orally a...
متن کاملEffects of methanolic extract of Moringa oleifera leaves on semen and biochemical parameters in cryptorchid rats.
While anti-oxidant effects of Moringa oleifera in much oxidative stress related diseases have been well reported, cryptorchidism on the other hand has been shown to cause oxidative stress. However, study is scanty on the likely role of Moringa oleifera in reducing cryptorchidism-induced oxidative stress in rats has not been studied. The present study looked into the effects of methanolic extrac...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Indian journal of experimental biology
دوره 42 6 شماره
صفحات -
تاریخ انتشار 2004